Infant with pallor and hepatosplenomegaly; not always a Leukemia

An infant with seizures, rash, and hepatosplenomegaly.

(See pages 451–2 for the Photo Quiz) Figure 2. Scalp of the infant, showing crusted erythematous erosion following a ruptured bullae. Figure 1. Scaly, erythematous erosions with collaretes of crust and numerous bullae covering the entire lower limbs of the neonate. Diagnosis: congenital syphilis. The infant's rapid plasma reagin test was reactive at a titer of 1:256 dilutions; a Treponema palli...

An infant with recurrent maculopapular rashes, anemia, lymphadenopathy, and hepatosplenomegaly.

Fever, hepatosplenomegaly, and pancytopenia in a 5-month-old infant.

Hepatosplenomegaly in a young child can be an ominous physical finding, potentially representing a metabolic, malignant, or infectious process. We present the case of a 5-month-old girl who had fever, hepatosplenomegaly, and hematologic abnormalities at the initial examination. This case demonstrates how a comprehensive understanding of the pathophysiologic characteristics of hepatosplenomegaly...

Chronic-phase chronic myeloid leukemia: Not always a reassuring diagnosis

Primary resistance to tyrosine-kinase inhibitors (TKIs) is quite uncommon in chronic-phase Chronic Myeloid Leukemia (CML) and related to still poorly understood mechanisms, as ABL mutations are rarely detected in primary resistant patients. We report the challenging case of a CML patient who was resistant to multiple TKIs because of different emerging ABL mutations and became pregnant while on ...

A premature girl with pallor and rash.

A 32-week girl was born by preterm delivery with birth weight of 1,600 g to a gravida 1 para 0 (G1P0) 26-year-old Hispanic mother. The mother’s past medical and gynecological history was unremarkable until 2 days before delivery, when she developed upper respiratory symptoms and received one dose of the second-generation cephalosporin. The infant was born by cesarean section because of abnormal...